N,N-二甲基-1H-吡唑-1-磺酰胺合成路线 （共 5 条）
反应条件
1: [3,2-c]pyrazole With sodium hydride in tetrahydrofuran T=20°C; 1 h; 2: N,N-dimethyl sulfamoyl chloride in tetrahydrofuran 1.5 h;
参考文献
Synthesis, , # 5 p. 793 - 798
反应条件
1: [3,2-c]pyrazole With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: N,N-dimethyl sulfamoyl chloride in tetrahydrofuran T=0 - 20°C; 2 h;
参考文献
WO2006/91671 A1, ;
Page/Page column 25 ;
WO 2006/091671 A1
反应条件
hydrogenchloride 21 h; Heating;
参考文献
Effenberger, Franz; Roos, Michael; Ahmad, Roshan; Krebs, Andreas
Chemische Berichte, 1991 , vol. 124, p. 1639 - 1650
反应条件
1: N,N-dimethylpyrazole-1-sulfonamide With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 0.5 h;
2: ethyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C;
参考文献
ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; ASTRAZENECA AB
Patent: WO2006/136829 A2, 2006 ;
Location in patent: Page/Page column 129-130 ;
WO 2006/136829 A2
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78 - -60°C; 0.25 h;
2: With 1,2-dibromo-1,1,2,2-tetrachloroethane in tetrahydrofuran; hexane
T=-70°C; 0.25 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2008/130021 A2, 2008 ;
Location in patent: Page/Page column 390-391 ;
