反应条件
1: 90 percent / aq. NaOH, NaI, n-Bu4NI / toluene / 24 h / 50 °C
2: 1.) Et3N, 2.) NaBH(OAc)3 / 1) CH2Cl2, rt, 15 min; 2) CH2Cl2, rt, 12 h
3: 68 percent / pivalic acid / 5 h / 150 °C
4: 1.) NaH / 1) THF, rt, 1 h; 2) THF, 0 deg C, 5 min, rt, 20 h
5: 15 percent / Pd(PPh3)4, aq. KOH / tetrahydrofuran / 1) rt, overnight; 2) reflux, 24 h
View Scheme
参考文献
Cossy, Janine; Belotti, Damien
Tetrahedron, 1999 , vol. 55, # 16 p. 5145 - 5156
