4-甲基-6-苯基哒嗪-3(2H)-酮合成路线 （共 18 条）
反应条件
1: 4-diethoxyphosphoryl-6-phenylpyridazin-3(2H)-one With sodium hydride in tetrahydrofuran T=20°C; 0.5 h; Inert atmosphere; 2: formaldehyd in tetrahydrofuran Horner-Wadsworth-Emmons olefination; 1.5 h; Reflux;
参考文献
Albrecht, Anna; Koszuk, Jacek; Kobucinski, Michal; Janecki, Tomasz
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 7 p. 1197 - 1200
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=150°C; Suzuki reaction; 0.5 h;
参考文献
de Araujo-Junior, Joao X.; Schmitt, Martine; Benderitter, Pascal; Bourguignon, Jean-Jacques
Tetrahedron Letters, 2006 , vol. 47, # 34 p. 6125 - 6128
反应条件
hydrogen iodide T=80°C; 5 h;
参考文献
Turck, A.; Ple, N.; Mojovic, L.; Queguiner, G.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 488 - 492
反应条件
1: 75 percent / Na2CO3 / Pd(PPh3)4 / toluene; ethanol / 12 h / Heating 2: 1.) n-butyllithium, 2,2,6,6-tetramethylpiperidine / 1.) hexane, 0 degC, 30 min, THF, -70 degC, 1.5 h; 2.) -70 degC, 2 h 3: 96 percent / 57percent hydroiodic acid / 5 h / 80 °C View Scheme
参考文献
Turck, A.; Ple, N.; Mojovic, L.; Queguiner, G.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 488 - 492
反应条件
sodium hydroxide; sulfuric acid; hydrazine
参考文献
Siddiqui, Anees A.; Wani, Sachin M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 7 p. 1574 - 1579
反应条件
1: 94.3 percent / hydrazine monohydrate / aq. ethanol / 2 h / Heating 2: 91.1 percent / CuCl2 / acetonitrile / 2 h / Heating View Scheme
参考文献
Hu, Wenhui; Ralay Ranaivo, Hantamalala; Roy, Saktimayee M.; Behanna, Heather A.; Wing, Laura K.; Munoz, Lenka; Guo, Ling; Van Eldik, Linda J.; Watterson, D. Martin
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 414 - 418
反应条件
1: pyridine / 2 h / 0 - 20 °C 2: 85 percent / Pd(PPh3)4; sodium carbonate / 1,2-dimethoxy-ethane; H2O / 0.5 h / 150 °C View Scheme
参考文献
de Araujo-Junior, Joao X.; Schmitt, Martine; Benderitter, Pascal; Bourguignon, Jean-Jacques
Tetrahedron Letters, 2006 , vol. 47, # 34 p. 6125 - 6128
反应条件
hydrogen iodide in ethanol 4 h; Heating;
参考文献
Moustafa, A. H.; Kaddah, A. M.; Shams, N. A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 12 p. 1084 - 1086
反应条件
1: 74 percent / aluminium chloride / 4 h / 100 °C 2: 79 percent / potassium carbonate / acetone / 4 h / Heating 3: 65 percent / hydrazine hydrate; sodium acetate / methanol / 8 h / Heating View Scheme
参考文献
Siddiqui, Anees A.; Wani, Sachin M.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 7 p. 1574 - 1579
反应条件
1: 74 percent / aluminium chloride / 4 h / 100 °C 2: 79 percent / potassium carbonate / acetone / 4 h / Heating 3: 65 percent / hydrazine hydrate; sodium acetate / methanol / 8 h / Heating View Scheme
参考文献
Dixon; Gregory; Wiggins
Journal of the Chemical Society, 1949 , p. 2139,2141
