1-叔丁基-4-亚甲基环己烷合成路线 （共 50 条）
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in diethyl ether
T=20°C; 0.5 h; Inert atmosphere;
2: 4-(1,1-dimethylethyl)cyclohexanone in diethyl ether
T=20°C; Wittig reaction; RefluxInert atmosphere;
参考文献
Cren, Sylvaine; Schar, Pascal; Renaud, Philippe; Schenk, Kurt
Journal of Organic Chemistry, 2009 , vol. 74, # 8 p. 2942 - 2946
反应条件
by a Wittig reaction;
参考文献
Cambie, Richard C.; Jurlina, Jeffrey L.; Rutledge, Peter S.; Woodgate, Paul D.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 315 - 326
反应条件
titanium tetrachloride; magnesium in tetrahydrofuran
T=0 - 20°C; 0.833333 h;
参考文献
Yan, Tu-Hsin; Tsai, Chia-Chung; Chien, Ching-Ting; Cho, Chia-Ching; Huang, Pei-Chen
Organic Letters, 2004 , vol. 6, # 26 p. 4961 - 4963
反应条件
(iPr)CuCl; triphenylphosphine; isopropyl alcohol in tetrahydrofuran; diethyl ether
T=60°C; 16 h;
参考文献
Lebel, Helene; Davi, Michael; Diez-Gonzalez, Silvia; Nolan, Steven P.
Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 144 - 149
反应条件
1: 3,5-bis(trifluoromethyl)phenyl methyl sulfone With (Me2N)3P=NH in tetrahydrofuran
0.5 h;
2: 4-(1,1-dimethylethyl)cyclohexanone in tetrahydrofuran
T=0 - 20°C; Julia-Kocienski methylenation; 16 h;
参考文献
Alonso, Diego A.; Fuensanta, Monica; Najera, Carmen; Varea, Montserrat
Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6404 - 6416
反应条件
1-n-butyl-3-methylimidazolium hexafluorophosphate in tetrahydrofuran; hexane
T=60°C; 6 h;
参考文献
Yoshino, Hideaki; Kobata, Masami; Yamamoto, Yuhei; Oshima, Koichiro; Matsubara, Seijiro
Chemistry Letters, 2004 , vol. 33, # 9 p. 1224 - 1224
反应条件
sodium hydride in dimethyl sulfoxide
参考文献
Paquette, Leo A.; Lobben, Paul C.
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5604 - 5616
反应条件
titanium(III) chloride in tetrahydrofuran
THF, reflux, 15 h;
参考文献
Welch, Steven C.; Loh, Jiann-Ping
Journal of Organic Chemistry, 1981 , vol. 46, # 20 p. 4072 - 4074
反应条件
in hexane; dichloromethane
T=25°C; 17 h;
参考文献
Piotrowski, Andrzej M.; Malpass, Dennis B.; Boleslawski, Marek P.; Eisch, John J.
Journal of Organic Chemistry, 1988 , vol. 53, # 12 p. 2829 - 2835
反应条件
methanesulfonyl chloride; triethylamine in dichloromethane
参考文献
Reich,H.J. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 6638 - 6648
