2,3-二氧代-2,3-二氢-1H-吲哚-5-磺酰氯合成路线 （共 9 条）
反应条件
trichlorophosphate in sulfolane T=60°C; 3 h;
参考文献
Washington University in St. Louis
Patent: US2009/68105 A1, 2009 ;
Location in patent: Page/Page column 9 ;
反应条件
trichlorophosphate in water; ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US6514992 B1, 2003 ;
US 6514992 B1
反应条件
trichlorophosphate in sulfolane T=60°C; 3 h; Inert atmosphere;
参考文献
Lawrence, Harshani R.; Pireddu, Roberta; Chen, Liwei; Luo, Yunting; Sung, Shen-Shu; Szymanski, Ann Marie; Yip, M. L. Richard; Guida, Wayne C.; Sebti, Said M.; Wu, Jie; Lawrence, Nicholas J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 4948 - 4956
反应条件
1.1: H2SO4; SO3 / -15 - 70 °C 1.2: 83 percent / aq. NaOH / pH 7 / cooling 2.1: 67 percent / tetramethylene sulfone; POCl3 / 3 h / 60 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6704 - 6715
反应条件
N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; 2.5 h; Inert atmosphere;
参考文献
CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; CARZANIGA, Laura; LA PORTA, Elena; GUALA, Matilde
Patent: WO2013/57013 A2, 2013 ;
Location in patent: Page/Page column 130; 131 ;
反应条件
triethylamine in tetrahydrofuran; dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2188 - 2191
反应条件
triethylamine in tetrahydrofuran; dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2188 - 2191
反应条件
ammonia; N-ethyl-N,N-diisopropylamine in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Lawrence, Harshani R.; Pireddu, Roberta; Chen, Liwei; Luo, Yunting; Sung, Shen-Shu; Szymanski, Ann Marie; Yip, M. L. Richard; Guida, Wayne C.; Sebti, Said M.; Wu, Jie; Lawrence, Nicholas J.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 16 p. 4948 - 4956
反应条件
triethylamine in tetrahydrofuran; dichloromethane
T=0 - 20°C; Inert atmosphere;
参考文献
Chu, Wenhua; Rothfuss, Justin; Chu, Yunxiang; Zhou, Dong; Mach, Robert H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 8 p. 2188 - 2191
