P-[[(1S)-2-[4-(苯甲酰氨基)-2-氧代-1(2H)-嘧啶基]-1-(羟甲基)乙氧基]甲基]膦酸二乙酯合成路线 （共 5 条）
反应条件
hydrogenchloride in dichloromethane T=0 - 5°C; 0.166667 h; Yield given;
参考文献
UNIVERSITY OF SOUTHERN CALIFORNIA (LA)
Patent: WO2006/14429 A2, 2006 ;
Location in patent: Page/Page column 11; figure 3 ;
WO 2006/014429 A2
反应条件
1: NaOH / dimethylformamide / 5 h / 105 °C 2: NaH / dimethylformamide / 6 h / 0 °C 3: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C View Scheme
参考文献
Brodfuehrer, Paul R.; Howell, Henry G.; Sapino, Chester Jr.; Vemishetti, Purushotham
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3243 - 3246
反应条件
1: NaH / dimethylformamide / 6 h / 0 °C 2: HCl(g) / CH2Cl2 / 0.17 h / 0 - 5 °C View Scheme
参考文献
Brodfuehrer, Paul R.; Howell, Henry G.; Sapino, Chester Jr.; Vemishetti, Purushotham
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3243 - 3246
反应条件
trimethylsilyl bromide in dichloromethane 18 h; Ambient temperature;
参考文献
UNIVERSITY OF SOUTHERN CALIFORNIA (LA)
Patent: WO2006/14429 A2, 2006 ;
Location in patent: Page/Page column 11; figure 3 ;
WO 2006/014429 A2
反应条件
1: TMSBr / CH2Cl2 / 18 h / Ambient temperature 2: conc. NH4OH / 4 h / Ambient temperature View Scheme
参考文献
Brodfuehrer, Paul R.; Howell, Henry G.; Sapino, Chester Jr.; Vemishetti, Purushotham
Tetrahedron Letters, 1994 , vol. 35, # 20 p. 3243 - 3246
