N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸合成路线 （共 50 条）
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran T=0°C; 15 h;
参考文献
Angewandte Chemie, , vol. 108, # 15 p. 1809 - 1812
反应条件
1: H2 / 5percent Pd/C / ethyl acetate / Ambient temperature 2: 0.25 h 3: 74 percent / CF3COOH / CH2Cl2 / 18 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 23 p. 3501 - 3507
反应条件
1: aq. Na2CO3 / methanol / 4 h / 23 °C 2: ethyl acetate 3: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 4: 80 percent / 1N HCl / methanol / 2 h / Heating 5: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: ethyl acetate 2: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 3: 80 percent / 1N HCl / methanol / 2 h / Heating 4: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 2: 80 percent / 1N HCl / methanol / 2 h / Heating 3: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 92 percent / Ba(OH)2*8H2O / H2O / 8 h / Heating 2: 74 percent / 10 percent aq. NaHCO3 / 6 h / 4 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 15 p. 4320 - 4323
反应条件
1: 1) LDA / 2a) THF, -78 deg C, 4 h, 2b) rt, overnight 2: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 3: 100 percent / 6 N HCl / 12 h / Heating 4: 70 percent / NaHCO3 / CH2Cl2; H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 5 p. 1681 - 1683
反应条件
1: 97 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / Ambient temperature 2: 100 percent / 6 N HCl / 12 h / Heating 3: 70 percent / NaHCO3 / CH2Cl2; H2O View Scheme
参考文献
Journal of Organic Chemistry, , vol. 56, # 5 p. 1681 - 1683
反应条件
hydrogenchloride T=20°C;
参考文献
Tetrahedron Letters, , vol. 44, # 2 p. 407 - 409
反应条件
1: 82 percent / CrO3; glacial AcOH / H2O / 5 °C 2: 80 percent / Et3N / H2O; acetone / 5 h / 0 - 20 °C 3: 85 percent / Et2NMe; H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 45, # 18 p. 3689 - 3691
