N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸合成路线 （共 50 条）
反应条件
1: 10.5 mg / NaHCO3 / ethyl acetate / 0.25 h / 0 °C 2: 89 percent / LiOH*H2O / tetrahydrofuran; methanol; H2O / 1 h / 20 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 44, # 20 p. 3096 - 3099
反应条件
1: p-TsOH / CH2Cl2 / 5 h / Ambient temperature 2: AcBr / CH2Cl2 / 2 h / -15 °C 3: NaN3 / dimethylformamide / 50 °C 4: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 5: 10percent aq. HCl / 2 h / Heating 6: aq. NaOH / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: 71 percent / (DHQ)2PHAL, NMO, K2OsO2(OH)4 / H2O; 2-methyl-propan-2-ol / 23 h / Ambient temperature 2: p-TsOH / CH2Cl2 / 5 h / Ambient temperature 3: AcBr / CH2Cl2 / 2 h / -15 °C 4: NaN3 / dimethylformamide / 50 °C 5: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 6: 10percent aq. HCl / 2 h / Heating 7: aq. NaOH / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 2: 10percent aq. HCl / 2 h / Heating 3: aq. NaOH / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: NaN3 / dimethylformamide / 50 °C 2: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 3: 10percent aq. HCl / 2 h / Heating 4: aq. NaOH / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: AcBr / CH2Cl2 / 2 h / -15 °C 2: NaN3 / dimethylformamide / 50 °C 3: H2 / 10percent Pd/C / methanol / 48 h / 760 Torr / Ambient temperature 4: 10percent aq. HCl / 2 h / Heating 5: aq. NaOH / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 17 p. 5104 - 5105
反应条件
1: 93 percent / DMAP / CH2Cl2 / 1 h / 23 °C 2: 74 percent / H2 / 10percent Pd-C / methanol / 4 h / 2585.7 Torr 3: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 90 percent / HNEt2*HBr, Et2AlCl / CH2Cl2 / 2.5 h / -15 °C 2: 80 percent / NaN3 / dimethylformamide / 40 h / 65 - 75 °C 3: 93 percent / DMAP / CH2Cl2 / 1 h / 23 °C 4: 74 percent / H2 / 10percent Pd-C / methanol / 4 h / 2585.7 Torr 5: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 74 percent / H2 / 10percent Pd-C / methanol / 4 h / 2585.7 Torr 2: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 80 percent / NaN3 / dimethylformamide / 40 h / 65 - 75 °C 2: 93 percent / DMAP / CH2Cl2 / 1 h / 23 °C 3: 74 percent / H2 / 10percent Pd-C / methanol / 4 h / 2585.7 Torr 4: 80 percent / aq. K2CO3 / methanol / 12 h / 23 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
