(2R,3S)-3-苯基异丝氨酸盐酸盐合成路线 （共 27 条）
反应条件
hydrogenchloride; water Heating;
参考文献
Tetrahedron Asymmetry, , vol. 21, # 6 p. 637 - 639
反应条件
1.1: sulfuric acid / 45 - 55 °C 1.2: pH 8 - 9 2.1: dichloromethane / 0.25 h / 20 °C View Scheme
参考文献
SHILPA MEDICARE LIMITED; SHRAWAT, Vimal Kumar; PUROHIT, Prashant; RAFIUDDIN, .
Patent: WO2012/117417 A1, 2012 ;
反应条件
1: NaOH / H2O View Scheme
参考文献
Kopczacki, Piotr; Gumulka, Maria; Masnyk, Marek; Grabarczyk, Halina; Nowak, Gerard; Daniewski, Wlodzimierz M.
Phytochemistry, 2001 , vol. 58, # 5 p. 775 - 787
反应条件
sodium hydrogencarbonate in dichloromethane; water 16 h; Ambient temperature;
参考文献
Ojima, Iwao; Habus, Ivan; Zhao, Mangzhu; Zucco, Martine; Park, Young Hoon; Sun, Chung Ming; Brigaud, Thierry
Tetrahedron, 1992 , vol. 48, # 34 p. 6985 - 7012
反应条件
sodium hydrogencarbonate in water; acetone
参考文献
Shen, Xin; Yang, Jidong; Zhan, Huaxing; Wang, Hu; Wu, Shaohong; Chen, Zili
Chinese Journal of Chemistry, 2013 , vol. 31, # 1 p. 31 - 36
反应条件
1: sodium hydrogencarbonate / acetone; water 2: triethylamine; tetra-(n-butyl)ammonium iodide / acetone / |Reflux 3: triethylamine; 4-(N,N-dimethlyamino)pyridine / dichloromethane 4: 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Reflux 5: 5 palladium on charcoal; hydrogen / ethyl acetate / 760.05 Torr 6: 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide / toluene / 15 - 20 °C 7: acetic acid; zinc / methanol / 0.5 h / |Reflux 8: trifluoroacetic acid / dichloromethane / 20 °C 9: sodium hydrogencarbonate; dihydrogen peroxide / water; tetrahydrofuran / 20 °C View Scheme
参考文献
Shen, Xin; Yang, Jidong; Zhan, Huaxing; Wang, Hu; Wu, Shaohong; Chen, Zili
Chinese Journal of Chemistry, 2013 , vol. 31, # 1 p. 31 - 36
反应条件
1: With sulfuric acid T=45 - 55°C; 2: With sodium hydrogencarbonate in dichloromethane; water pH=8 - 9;
参考文献
SHILPA MEDICARE LIMITED; SHRAWAT, Vimal Kumar; PUROHIT, Prashant; RAFIUDDIN, .
Patent: WO2012/117417 A1, 2012 ;
Location in patent: Page/Page column 9; 11 ;
