2,5-二溴-3-甲基噻吩合成路线 （共 15 条）
反应条件
benzyltrimethylammonium bromide dibromide; zinc(II) chloride in acetic acid 15 h; Ambient temperature;
参考文献
Okamoto, Tsuyoshi; Kakinami, Takaaki; Fujimoto, Hiroshi; Kajigaeshi, Shoji
Bulletin of the Chemical Society of Japan, 1991 , vol. 64, # 8 p. 2566 - 2568
反应条件
dihydrogen peroxide; NH4Br; acetic acid in water 20 h; Green chemistry; TimeSolventReagent/catalyst; regioselective reaction;
参考文献
Canadian Journal of Chemistry, , vol. 91, # 8 p. 679 - 683
反应条件
1: thien-2-yl bromide With magnesium in diethyl ether Grignard reaction; homocoupling; 2: 2,5-dibromo-3-methylthiophene With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether Substitution; 3 h;
参考文献
Chaloner, Penny A.; Gunatunga, Sumudu R.; Hitchcock, Peter B.
Journal of the Chemical Society. Perkin Transactions 2, 1997 , # 8 p. 1597 - 1604
反应条件
1: NBS / CCl4 2: 50 percent / NaH 3: 1.) NaOH; 2.) HCl 4: 200 °C 5: 100 percent / SOCl2 6: 60 percent / AlCl3 7: Zn/CH3COOH View Scheme
参考文献
Garreau, R.; Roncali, J.; Garnier, F.; Lemaire, M.
Journal de Chimie Physique et de Physico-Chimie Biologique, 1989 , vol. 86, # 1 p. 93 - 98
反应条件
1: NBS / CCl4 2: 50 percent / NaH 3: 1.) NaOH; 2.) HCl 4: 200 °C View Scheme
参考文献
Garreau, R.; Roncali, J.; Garnier, F.; Lemaire, M.
Journal de Chimie Physique et de Physico-Chimie Biologique, 1989 , vol. 86, # 1 p. 93 - 98
反应条件
1: With tetra-n-butylammonium tetrafluoroborate; zinc dibromide; NiBr2bipy in N,N-dimethyl-formamide T=-10.16°C; Electrolysis; 2: in N,N-dimethyl-formamide Acid hydrolysis; Further stages.;
参考文献
Mellah; Labbe; Nedelec; Perichon
New Journal of Chemistry, 2001 , vol. 25, # 2 p. 318 - 321
反应条件
1: 83 percent / n-bromosuccinimide; benzoyl peroxide / CCl4 / 3 h / Heating 2: 2 h / 160 °C View Scheme
参考文献
Hou, Jianhui; Yang, Chunhe; He, Chang; Li, Yongfang
Chemical Communications, 2006 , # 8 p. 871 - 873
反应条件
1: 83 percent / Br2, azobisisobutyronitril (AIBN) / CCl4 / 5 h / Heating 2: 1.) Na2CO3, 2.) aq. HCl / 1.) EtOH, water, reflux, 12 h, 2.) EtOH, ether, reflux, 1 h View Scheme
参考文献
Coyle, John D.; Haws, Edmund J.; Oduntan, Olufemi; Rogers, John T.
Heterocycles, 1984 , vol. 22, # 5 p. 1175 - 1178
反应条件
1: 2,5-dibromo-3-methylthiophene With tris-(dibenzylideneacetone)dipalladium(0); [(t-Bu)3PH]BF4 in tetrahydrofuran 0.25 h; 2: dihydroxy-thien-2-ylborane With potassium phosphate in tetrahydrofuran; water 3 h; Heating / reflux;
参考文献
MERCK PATENT GMBH
Patent: WO2005/80369 A2, 2005 ;
Location in patent: Page/Page column 38-39 ;
反应条件
[1,3-bis(diphenylphosphino) propane] dichloronickel(II) in diethyl ether 16 h; Heating;
参考文献
Pham, Chiem Van; Burkhardt, A.; Shabana, R.; Cunningham, David D.; Mark, Harry B.; Zimmer, Hans
Phosphorus, Sulfur and Silicon and the Related Elements, 1989 , vol. 46, p. 153 - 168
