Z-GLY-GLY-PHE-OH合成路线 （共 11 条）
反应条件
TEA in tetrahydrofuran; water; N,N-dimethyl-formamide T=20°C; Condensation; 16 h;
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 4 p. 664 - 674
反应条件
Tris buffer; triethylamine; α-chymotrypsin in acetonitrile T=30°C; Acylation; pH=7.8; 0.0833333 h;
参考文献
Chemistry Letters, , # 10 p. 1013 - 1014
反应条件
Tris buffer; triethylamine; α-chymotrypsin in acetonitrile T=30°C; Acylation; pH=7.8; 0.0833333 h;
参考文献
Chemistry Letters, , # 10 p. 1013 - 1014
反应条件
1: 50 percent / Et3N / tetrahydrofuran; H2O / 20 °C 2: 100 percent / HOBT / CH2Cl2 3: 58 percent / TEA / tetrahydrofuran; dimethylformamide; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 4 p. 664 - 674
反应条件
1: 100 percent / HOBT / CH2Cl2 2: 58 percent / TEA / tetrahydrofuran; dimethylformamide; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 4 p. 664 - 674
反应条件
Tris buffer; triethylamine; α-chymotrypsin in acetonitrile T=30°C; Acylation; pH=7.8; 0.0833333 h;
参考文献
Chemistry Letters, , # 10 p. 1013 - 1014
反应条件
1: N-methylmorpholine / tetrahydrofuran / 0.17 h / -20 °C 2: tetrahydrofuran; H2O; dimethylformamide / 1 h / Ambient temperature 3: hydrogen / 10percent Pd/C / methanol / 8 h / Ambient temperature View Scheme
参考文献
Sugg; Portoghese
Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 2028 - 2033
反应条件
hydrogenchloride; N-lt;lt;lt;(benzyloxycarbonyl)aminogt;methylgt;hydroxyphosphinylgt;-L-phenylalanine; tri-(hydroxymethyl)-methylamine; sodium chloride; carboxypeptidase A in water T=25°C; competitive inhibition of CPA-catalyzed peptide hydrolysis, Ki; Michaelis-Menton kinetics; Mechanism;
参考文献
Jacobsen,N.E.; Bartlett,P.A.
Journal of the American Chemical Society, 1981 , vol. 103, p. 654
反应条件
hydrogen; 10percent Pd/C in methanol T=25°C; Hydrogenolysis; P=1551.49 Torr; 3 h;
参考文献
Ganellin, C. Robin; Bishop, Paul B.; Bambal, Ramesh B.; Chan, Suzanne M. T.; Law, James K.; Marabout, Benoit; Luthra, Pratibha Mehta; Moore, Andrew N. J.; Peschard, Olivier; Bourgeat, Pierre; Rose, Christiane; Vargas, Froylan; Schwartz, Jean-Charles
Journal of Medicinal Chemistry, 2000 , vol. 43, # 4 p. 664 - 674
参考文献
Miyazawa, Toshifumi; Ensatsu, Eiichi; Hiramatsu, Makoto; Yanagihara, Ryoji; Yamada, Takashi
Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 3 p. 396 - 401
