2-(4-氯苯甲酰基)吡咯合成路线 （共 11 条）
反应条件
zinc oxide in neat (no solvent) T=20°C; Friedel-Crafts Acylation; 0.0666667 h; Green chemistry; regioselective reaction;
参考文献
Zhang, Shuguang; Feng, Chengliang; Cai, Jin; Chen, Junqing; Hu, Huayou; Ji, Min
Journal of Chemical Research, 2013 , vol. 37, # 8 p. 480 - 482
反应条件
tetrafluoroboric acid; mercury(II) oxide in dimethyl sulfoxide T=60°C; 0.5 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Degani, Iacopo; Dughera, Stefano; Fochi, Rita; et al.
Gazzetta Chimica Italiana, 1990 , vol. 120, # 10 p. 619 - 627
反应条件
tetrafluoroboric acid; mercury(II) oxide in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Degani, Iacopo; Fochi, Rita; Gatti, Antonella; Regondi, Valeria
Journal of Organic Chemistry, 1988 , vol. 53, # 10 p. 2245 - 2250
反应条件
NaOAc·3H2O in anhydrous dichloroethane; water; 1,2-dichloro-ethane
参考文献
McNeil Laboratories, Inc.
Patent: US4002643 A1, 1977 ;
反应条件
1: N-Pyrrolyl-lithium With zirconium tetrachloride in tetrahydrofuran; cyclohexane T=-78°C; 0.333333 h; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran; cyclohexane T=-78 - 45°C; Inert atmosphere; 3: 4-chlorobenzoic acid methyl ester in tetrahydrofuran; cyclohexane T=45°C; 48 h; Inert atmosphere;
参考文献
Sharma, Ratnesh; Chouhan, Mangilal; Nair, Vipin A.
Tetrahedron Letters, 2010 , vol. 51, # 15 p. 2039 - 2043
反应条件
1: N-Pyrrolyl-lithium With zirconium tetrachloride in tetrahydrofuran; cyclohexane T=-78°C; 0.333333 h; Inert atmosphere; 2: With n-butyllithium in tetrahydrofuran; cyclohexane T=-78 - 45°C; Inert atmosphere; 3: 4-chlorobenzaldehyde in tetrahydrofuran; cyclohexane T=45°C; 48 h; Inert atmosphere;
参考文献
Sharma, Ratnesh; Chouhan, Mangilal; Nair, Vipin A.
Tetrahedron Letters, 2010 , vol. 51, # 15 p. 2039 - 2043
反应条件
1: 66 percent / pyridine / acetonitrile / 0.5 h / Ambient temperature 2: 100 percent / HgO, aq. HBF4 / tetrahydrofuran / 1 h / Ambient temperature View Scheme
参考文献
Barbero, Margherita; Cadamuro, Silvano; Degani, Iacopo; Fochi, Rita; Gatti, Antonella; Regondi, Valeria
Journal of Organic Chemistry, 1988 , vol. 53, # 10 p. 2245 - 2250
反应条件
1: thionyl chloride 2: 32 percent / AlCl3 / Heating View Scheme
参考文献
Barbero, Margherita; Cadamuro, Silvano; Degani, Iacopo; Dughera, Stefano; Fochi, Rita; et al.
Gazzetta Chimica Italiana, 1990 , vol. 120, # 10 p. 619 - 627
反应条件
trifluoroacetic acid T=72°C; 36 h; equilibrium;
参考文献
Carson, John R.; Davis, Nancy M.
Journal of Organic Chemistry, 1981 , vol. 46, # 5 p. 839 - 843
反应条件
Yield given. Multistep reaction;
参考文献
Massa; Ragno; Porretta; Mai; Retico; Artico; Simonetti
Archiv der Pharmazie, 1993 , vol. 326, # 9 p. 539 - 546
