1: 75 percent / Rexyn 300,mixed acid-base ion exchanger resin / tetrahydrofuran / 12 h / 40 °C 2: diisobutylaluminium hydride / tetrahydrofuran / -78 °C 3: 87 percent / B(OH)3 / W-2-Raney nickel / methanol; H2O / 25 °C 4: 53 percent / Rexyn 300 / H2O; tetrahydrofuran / 6 h / Heating View Scheme

1: 90 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; tetrahydrofuran / 22 h / 20 °C 2: DMAP / diethyl ether / 5 h / 20 °C 3: 0.23 g / DMAP / CH2Cl2 / 2 h / 20 °C 4: 58 percent / aq. HCl / 12 h / Heating View Scheme

1: 75 percent / Rexyn 300,mixed acid-base ion exchanger resin / tetrahydrofuran / 12 h / 40 °C 2: diisobutylaluminium hydride / tetrahydrofuran / -78 °C View Scheme

1: 75 percent / Rexyn 300,mixed acid-base ion exchanger resin / tetrahydrofuran / 12 h / 40 °C 2: diisobutylaluminium hydride / tetrahydrofuran / -78 °C 3: 87 percent / B(OH)3 / W-2-Raney nickel / methanol; H2O / 25 °C View Scheme

1: 75 percent / Rexyn 300,mixed acid-base ion exchanger resin / tetrahydrofuran / 12 h / 40 °C 2: B(OH)3 / W-2-Raney nickel / methanol; H2O / 1.5 h / 25 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: DMAP / diethyl ether / 4 h / 20 &deg;C<br />2: 1.79 g / sodium borohydride / ethanol / 2 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: ozone; Na₂CO₃ / CH₂Cl₂; methanol / -78 &deg;C<br />1.2: 94 percent / Et₃N; Ac₂O / CH₂Cl₂ / 0 - 20 &deg;C<br />2.1: 94 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; tetrahydrofuran / 15 h / 20 &deg;C<br />3.1: DMAP / diethyl ether / 4 h / 20 &deg;C<br />4.1: 1.79 g / sodium borohydride / ethanol / 2 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 94 percent / potassium tert-butoxide / 2-methyl-propan-2-ol; tetrahydrofuran / 15 h / 20 &deg;C<br />2: DMAP / diethyl ether / 4 h / 20 &deg;C<br />3: 1.79 g / sodium borohydride / ethanol / 2 h / 20 &deg;C<br /> <br /> &nbsp;