(3R)-3-[[(叔丁基)二甲基硅烷基]氧基]戊二酸 1-[(R)-羧基苯基甲基]酯合成路线 （共 3 条）
反应条件
sodium methylate T=7°C; 0.5 h;
参考文献
Konoike; Araki
Journal of Organic Chemistry, 1994 , vol. 59, # 25 p. 7849 - 7854
反应条件
1.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice 1.3: pH 6.5 2.1: triethylamine / hexane / 3 h / -40 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C 3.2: 3 h / -78 °C 4.1: acetonitrile / 20 h / Reflux 4.2: 3 h / 20 °C / Cooling with ice View Scheme
参考文献
MATRIX LABORATORIES LTD.; SETHI, Madhuresh, Kumar; MAHAJAN, Sanjay; RAWAT, Vijendra, Singh; MARA, Bhairaiah; VEERA, Upendra, Nath; DATTA, Debashish
Patent: WO2011/141934 A1, 2011 ;
反应条件
1.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice 1.3: pH 6.5 2.1: triethylamine / hexane / 3 h / -40 °C 3.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / 0 °C 3.2: 3 h / -78 °C View Scheme
参考文献
MATRIX LABORATORIES LTD.; SETHI, Madhuresh, Kumar; MAHAJAN, Sanjay; RAWAT, Vijendra, Singh; MARA, Bhairaiah; VEERA, Upendra, Nath; DATTA, Debashish
Patent: WO2011/141934 A1, 2011 ;
