1,4-二氟-5,8-二羟基蒽醌合成路线 （共 22 条）
反应条件
1.1: Zn; NaOH / H2O / 6 h / 70 - 80 °C 2.1: Zn; NaOH / H2O / 5 h / 95 - 100 °C 3.1: toluene / Heating 4.1: KF; NaF / 130 - 270 °C / 20 Torr 4.2: NaCl; AlCl3 / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 19 p. 2755 - 2758
反应条件
1.1: NaOH; H2O / 0.75 h / Heating 2.1: Zn; NaOH / H2O / 6 h / 70 - 80 °C 3.1: Zn; NaOH / H2O / 5 h / 95 - 100 °C 4.1: toluene / Heating 5.1: KF; NaF / 130 - 270 °C / 20 Torr 5.2: NaCl; AlCl3 / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 19 p. 2755 - 2758
反应条件
1.1: toluene / Heating 2.1: KF; NaF / 130 - 270 °C / 20 Torr 2.2: NaCl; AlCl3 / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 19 p. 2755 - 2758
反应条件
1.1: Zn; NaOH / H2O / 5 h / 95 - 100 °C 2.1: toluene / Heating 3.1: KF; NaF / 130 - 270 °C / 20 Torr 3.2: NaCl; AlCl3 / 4 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 19 p. 2755 - 2758
反应条件
1: 130 °C / 0.05 Torr 2: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
in tetrahydrofuran T=50°C; 20 h; Inert atmosphere;
参考文献
Mansour, Oula C.; Evison, Benny J.; Sleebs, Brad E.; Watson, Keith G.; Nudelman, Abraham; Rephaeli, Ada; Buck, Damian P.; Collins, J. Grant; Bilardi, Rebecca A.; Phillips, Don R.; Cutts, Suzanne M.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 6851 - 6866
反应条件
in pyridine 50 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 8 p. 2373 - 2380
反应条件
ammonium hydroxide in pyridine T=110°C; 3 h;
参考文献
Yang, Liu; Peacey, Eleanor; Dickson, John; Donahue, Christine P.; Zheng, Suxin; Varani, Gabriele; Wolfe, Michael S.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6523 - 6526
反应条件
in pyridine T=90°C; 1 h; Inert atmosphere;
参考文献
Yang, Liu; Peacey, Eleanor; Dickson, John; Donahue, Christine P.; Zheng, Suxin; Varani, Gabriele; Wolfe, Michael S.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6523 - 6526
反应条件
pyridine
48 h; Ambient temperature;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
