1,4-二氟-5,8-二羟基蒽醌合成路线 （共 22 条）
反应条件
AlCl3, aluminium chloride; sodium chloride T=220°C; 3 h;
参考文献
SCHOOL OF PHARMACY, UNIVERSITY OF LONDON
Patent: WO2005/61453 A1, 2005 ;
Location in patent: Page/Page column 19 ;
反应条件
hydrogenchloride; hydroquinone; sodium chloride; AlCl3
反应条件
boron tribromide in dichloromethane a.) from -78 deg C to -60 deg C, b.) RT, overnight;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 80 percent / diethylamine / diethyl ether 2: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min 3: H2SO4 / H2O / 1 h / Heating 4: 130 °C / 0.05 Torr 5: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 1.) n-BuLi / 1.) THF, -78 deg C, 1 h, 2.) -65 deg C, 15 min 2: H2SO4 / H2O / 1 h / Heating 3: 130 °C / 0.05 Torr 4: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 3,6-dichloro-phthalic acid anhydride With potassium fluoride; NAF T=130 - 270°C; Fluorination; P=20 Torr; 2: hydroquinone With aluminium trichloride; sodium chloride Cycloaddition; Friedel-Crafts reaction; 4 h; Heating;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 19 p. 2755 - 2758
反应条件
1: H2SO4 / H2O / 1 h / Heating 2: 130 °C / 0.05 Torr 3: 89 percent / AlCl3, NaCl / 1.5 h / 220 °C View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 58 percent / chromium trioxide, water / acetic acid / 12 h 2: 75 percent / BBr3 / CH2Cl2 / a.) from -78 deg C to -60 deg C, b.) RT, overnight View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
1: 96 percent / trifluoroacetic anhydride / CH2Cl2 / 6 h 2: 58 percent / chromium trioxide, water / acetic acid / 12 h 3: 75 percent / BBr3 / CH2Cl2 / a.) from -78 deg C to -60 deg C, b.) RT, overnight View Scheme
参考文献
Synthetic Communications, , vol. 20, # 14 p. 2139 - 2146
反应条件
aluminium trichloride; sodium chloride Heating;
参考文献
Krapcho, A. Paul; Getahun, Zelleka; Avery, Kenneth J.
Synthetic Communications, 1990 , vol. 20, # 14 p. 2139 - 2146
