3-羟基苯并[B]噻吩-2-羧酸甲酯合成路线 （共 17 条）
反应条件
2: sulfuric acid View Scheme
参考文献
Monatshefte fuer Chemie, , vol. 35, p. 1046
反应条件
1: alkali; sodium sulfide 2: alkali 3: hydrogen chloride 4: alcoholic NaOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 39, p. 1062
Justus Liebigs Annalen der Chemie, , vol. 351, p. 407
反应条件
1: hydrogen chloride 2: alcoholic NaOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 39, p. 1062
Justus Liebigs Annalen der Chemie, , vol. 351, p. 407
反应条件
in dimethyl sulfoxide
参考文献
Eli Lilly and Company
Patent: US3989718 A1, 1976 ;
反应条件
1: potassium tert-butylate / dimethyl sulfoxide / 20 °C
2: pyridine / Reflux
View Scheme
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
1: 1) potassium t-butoxide / 2) 75 deg C, 24 h
2: 65 percent / 96 h / Ambient temperature
3: 50 percent / 20percent aqueous NaOH / ethanol / 3 h / Heating
4: 65 percent / 0.5 h / 182 °C / 0.1 Torr
View Scheme
参考文献
Conde; Corral; Lissavetzky
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 937 - 940
反应条件
1: 1) potassium t-butoxide / 2) 75 deg C, 24 h
2: 21 percent / 360 h / Ambient temperature
3: 55 percent / 20percent aqueous NaOH / ethanol / 3 h / Heating
4: 69 percent / 0.5 h / 185 °C / 0.1 Torr
View Scheme
参考文献
Conde; Corral; Lissavetzky
Journal of Heterocyclic Chemistry, 1980 , vol. 17, # 5 p. 937 - 940
