3-羟基苯并[B]噻吩-2-羧酸甲酯合成路线 （共 17 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in toluene T=20°C; 24 h;
参考文献
Hansen, Finn K.; Khankischpur, Mehdi; Tolaymat, Ibrahim; Mesaros, Renata; Dannhardt, Gerd; Geffken, Detlef
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 15 p. 5031 - 5034
反应条件
hydrogen; triethylamine; cobalt in tetrahydrofuran T=100°C; Hydrogenation; cyclization; hydrogenolysis; P=62057.8 Torr; 14 h;
参考文献
Khatana, Sonya S.; Boschelli, Diane H.; Kramer, James B.; Connor, David T.; Barth, Hubert; Stoss, Peter
Journal of Organic Chemistry, 1996 , vol. 61, # 17 p. 6060 - 6062
反应条件
potassium tert-butylate in tetrahydrofuran 29 h;
参考文献
Australian Journal of Chemistry, , vol. 61, # 7 p. 484 - 499
反应条件
1: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran T=0°C; Inert atmosphere; 2: 2,2'-dithiodibenzoyl chloride in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
Gopinath, Pushparathinam; Nilaya, Surapaneni; Debi, Tripathy Ranjan; Ramkumar, Venkatachalam; Muraleedharan, Kannoth Manheri
Chemical Communications, 2009 , # 46 p. 7131 - 7133
反应条件
hydrogen; palladium on activated charcoal Hydrogenation;
参考文献
Journal of Organic Chemistry, , vol. 61, # 17 p. 6060 - 6062
反应条件
1.1: TMEDA; BuLi / hexane / 1.25 h / 40 - 58 °C 1.2: 71 percent / hexane; diethyl ether / 2 h / -80 °C 2.1: 72 percent / LDA / hexane; diethyl ether; tetrahydrofuran / 2 h / -80 °C View Scheme
参考文献
Tetrahedron, , vol. 58, # 22 p. 4529 - 4533
反应条件
1: 60 percent / aq. H2O2 / trifluoroacetic acid 2: 50 percent / CF3COOH / methanol / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 54, # 49 p. 14811 - 14824
反应条件
1: alkali 2: hydrogen chloride 3: alcoholic NaOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 39, p. 1062
Justus Liebigs Annalen der Chemie, , vol. 351, p. 407
反应条件
1: NaOH-solution / 50 - 60 °C 2: hydrogen chloride 3: alcoholic NaOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 39, p. 1062
Justus Liebigs Annalen der Chemie, , vol. 351, p. 407
反应条件
1: hydrogen chloride 2: alcoholic NaOH-solution View Scheme
参考文献
Chemische Berichte, , vol. 39, p. 1062
Justus Liebigs Annalen der Chemie, , vol. 351, p. 407
