potassium carbonate in acetone 24 h; Ambient temperature;

1: 39 percent / oxygen, hexamethylphosphoric triamide, copper(I) chloride / bis(acetonitrile)dichloropalladium(II) / 1,2-dimethoxy-ethane / 24 h / 50 °C 2: 62 percent / Amberlyst-15, water / acetone / 24 h / Ambient temperature 3: 85 percent / K2CO3 / acetone / 24 h / Ambient temperature View Scheme

1: 62 percent / Amberlyst-15, water / acetone / 24 h / Ambient temperature 2: 85 percent / K2CO3 / acetone / 24 h / Ambient temperature View Scheme

1: tetrakis<triphenylphosphine>-palladium / tetrahydrofuran View Scheme

sulfuric acid

trimethylamine anschliessend Umsetzung mit KCN;

Yield given. Multistep reaction. Yields of byproduct given;

in toluene 9 h; Heating;