Boc-L-苯丙氨酰-苯丙氨酸合成路线 （共 18 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=0 - 20°C; 3.5 h;
参考文献
NEUROCHEM (INTERNATIONAL) LIMITED
Patent: WO2004/113275 A2, 2004 ;
Location in patent: Page 158; 159 ;
反应条件
sodium hydroxide in 1,4-dioxane; water 2 h; Ambient temperature;
参考文献
Ewenson, A; Laufer, R; Frey, J; Chorev, M; Selinger, Z; Gilon, C
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 179 - 186
反应条件
sodium hydrogencarbonate in ethanol; water; acetone T=20°C; 5 h;
参考文献
Popovic, Stanimir; Bieraeugel, Hans; Detz, Remko J.; Kluwer, Alexander M.; Koole, Jelmer A. A.; Streefkerk, Dieuwertje E.; Hiemstra, Henk; Van Maarseveen, Jan H.
Chemistry - A European Journal, 2013 , vol. 19, # 50 p. 16934 - 16937
反应条件
phosphate buffer; oxygen; tyrosinase in water; acetonitrile T=20°C; pH=7.0; 108 h;
参考文献
Voelkert, Martin; Koul, Surrinder; Mueller, Gernot H.; Lehnig, Manfred; Waldmann, Herbert
Journal of Organic Chemistry, 2002 , vol. 67, # 20 p. 6902 - 6910
反应条件
trimethylaluminum in 1,2-dichloro-ethane T=80°C;
参考文献
Martin, Stephen F.; Dwyer, Michael P.; Lynch, Christopher L.
Tetrahedron Letters, 1998 , vol. 39, # 12 p. 1517 - 1520
反应条件
1: N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide*HCl; N-hydroxybenzotriazole; N-methylmorpholine / dimethylformamide / 12 h / 20 °C 2: aq. NaOH / tetrahydrofuran / 10 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 1102 - 1106
反应条件
1: 91 percent / KOH (2N), NEt3 / ethyl acetate; toluene / 2 h / Ambient temperature 2: 81 percent / NEt3, 0.5 N KOH/EtOH / toluene; aq. ethanol / 2 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , p. 331 - 336
反应条件
1: SOCl2 / 5 h / 20 °C 2: N-ethyl-N'-(3-dimethylaminopropyl)-carbodiimide*HCl; N-hydroxybenzotriazole; N-methylmorpholine / dimethylformamide / 12 h / 20 °C 3: aq. NaOH / tetrahydrofuran / 10 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 4 p. 1102 - 1106
反应条件
potassium hydroxide; triethylamine in ethanol; toluene 2 h; Ambient temperature;
参考文献
Gruszecki, Wojciech; Gruszecka, Maria; Bradaczek, Hans
Liebigs Annalen der Chemie, 1988 , p. 331 - 336
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 1 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 18, # 23 p. 8365 - 8373
