反应条件
1: 99 percent / methanol / 1.5 h / Heating 2: H2 / Pd/C / methanol / 17 h 3: 27 percent / AcOH / CH2Cl2 / 72 h / 20 °C 4: SOCl2 / 1,2-dichloro-ethane; dimethylformamide / 0.42 h / Heating 5: 90 percent / conc. HCl / 1 h / 90 °C 6: Et3N / acetone / 0.25 h / 0 °C 7: 1.) NaN3, 2.) 8 M HCl / 1.) Me2CO, H2O, 0 deg C, 30 min, 2.) reflux, 10 min 8: 60 percent / methanol / 24 h / 20 °C View Scheme
参考文献
Gourdie; Valu; Gravatt; Boritzki; Baguley; Wakelin; Wilson; Woodgate; Denny
Journal of Medicinal Chemistry, 1990 , vol. 33, # 4 p. 1177 - 1186
