(S)-(+)-2-羟基-2-苯丙酸合成路线 （共 31 条）
反应条件
1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 2: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
反应条件
1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 2: 96 percent / tetrahydrofuran / -78 - 20 °C 3: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 4: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
反应条件
1: 96 percent / tetrahydrofuran / -78 - 20 °C 2: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 3: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
反应条件
1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 2: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
反应条件
1: 77 percent / benzene / Heating; water sep. by a Dean-Stark trap 2: -70 °C 3: 2percent HCl / ethanol / 4 h / Heating 4: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 43, # 21 p. 4979 - 4988
反应条件
1: -70 °C 2: 2percent HCl / ethanol / 4 h / Heating 3: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 43, # 21 p. 4979 - 4988
反应条件
1: 2percent HCl / ethanol / 4 h / Heating 2: NaClO2, KH2PO4, 2-methyl-2-butene / acetone; H2O / 0.75 h / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 43, # 21 p. 4979 - 4988
反应条件
1: 1) LiN(i-Pr)2, HMPT / 1) -70 deg C, THF, 2) -70 to 0 deg C, 10 min 2: KOH / H2O; methanol / 0.17 h / 60 °C / e.e.: 85percent View Scheme
参考文献
Tetrahedron Letters, , vol. 22, # 42 p. 4221 - 4224
反应条件
1: 81 percent / 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride, 4-dimethylaminopyridine / CH2Cl2 / 1 h / Heating 2: diethyl ether / 1 h / -78 °C 3: 93 percent / 20percent ethanolic KOH / ethanol / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 4 p. 957 - 959
反应条件
1: diethyl ether / 1 h / -78 °C 2: 93 percent / 20percent ethanolic KOH / ethanol / 3 h / Heating View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 4 p. 957 - 959
