(S)-(+)-2-羟基-2-苯丙酸合成路线 （共 31 条）
反应条件
sodium chlorite; potassium dihydrogenphosphate; 2-methyl-but-2-ene in water; acetone 0.75 h; Ambient temperature; Yield given;
参考文献
Tetrahedron, , vol. 43, # 21 p. 4979 - 4988
反应条件
potassium hydroxide in methanol; water Yield given;
参考文献
Journal of the American Chemical Society, , vol. 106, # 10 p. 2943 - 2948
反应条件
1: 83 percent / tetrahydrofuran; diethyl ether / 3 h / -78 °C 2: NCS, AgNO3 / H2O; acetonitrile 3: I2, KOH / 43 °C 4: KOH / methanol; H2O View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 10 p. 2943 - 2948
反应条件
1: NCS, AgNO3 / H2O; acetonitrile 2: I2, KOH / 43 °C 3: KOH / methanol; H2O View Scheme
参考文献
Journal of the American Chemical Society, , vol. 106, # 10 p. 2943 - 2948
反应条件
sodium hydroxide T=75°C; 48 h; enantioselective reaction;
参考文献
Angewandte Chemie, International Edition, , vol. 48, p. 2391 - 2393
Angewandte Chemie, , vol. 121, p. 2427 - 2429
反应条件
1.1: 60 percent / p-TsOH; H2SO4 / pentane / 24 h / Heating 2.1: lithium diisopropylamine / hexane; diethyl ether / 0.5 h / -78 °C 2.2: hexane; diethyl ether / 2 h / -78 °C 3.1: aq. KOH / methanol / 3 h / Heating View Scheme
参考文献
Journal of Chemical Research, , # 12 p. 816 - 817
反应条件
potassium hydroxide in methanol; water T=60°C; 0.166667 h; e.e.: 85percent; Title compound not separated from byproducts;
参考文献
Tetrahedron Letters, , vol. 22, # 42 p. 4221 - 4224
反应条件
(S)-pinacolyl alcohol partielle asymmetrische Synthese;
参考文献
Helvetica Chimica Acta, , vol. 39, p. 1086,1092
反应条件
1.1: p-toluenesulfonic acid / CH2Cl2 / 5 h / 20 °C 1.2: 0.8 g / potassium carbonate / tetrahydrofuran / 24 h / 20 °C 2.1: 96 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 20 °C 3.1: 96 percent / tetrahydrofuran / -78 - 20 °C 4.1: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 5.1: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
反应条件
1: tetrahydrofuran / -78 - 20 °C 2: silver(I) nitrate; N-chlorosuccinimide / acetonitrile; H2O / 0 - 4 °C 3: silver(I) oxide / tetrahydrofuran; H2O / 0.25 h / cooling View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 16, # 10 p. 1837 - 1843
