四氢-2H-吡喃-2-乙酸合成路线 （共 13 条）
反应条件
sodium hydroxide T=20°C; 6 h;
参考文献
Palmer, Robert J.; Stirling, Charles J. M.
Journal of the American Chemical Society, 1980 , vol. 102, # 27 p. 7888 - 7892
反应条件
boron trifluoride diethyl etherate in dichloromethane T=0°C;
参考文献
Mead, Keith T.; Samuel, Beverly
Tetrahedron Letters, 1988 , vol. 29, # 50 p. 6573 - 6576
反应条件
piperidine; acetic acid in dimethyl sulfoxide T=20 - 100°C; 4.5 h; Inert atmosphere;
参考文献
Poeplau, Petra; Frank, Sarah; Morinaka, Brandon I.; Piel, Joern
Angewandte Chemie - International Edition, 2013 , vol. 52, # 50 p. 13215 - 13218
Angew. Chem., 2013 , vol. 125, p. 13457 - 13460
反应条件
potassium hydroxide in various solvent(s) 5 h; Heating;
参考文献
Maciejewski, Lucien; Martin, Marius; Ricart, Gui; Brocard, Jacques
Synthetic Communications, 1988 , vol. 18, # 15 p. 1757 - 1762
反应条件
piperidine; acetic acid in dimethyl sulfoxide 1.) r.t., 30 min, 2.) 100 deg C, 3 - 4 h;
参考文献
Synthesis, , # 1 p. 84 - 86
反应条件
1: boron trifluoride etherate / CH2Cl2 / 0 °C 2: 71 percent / potassium fluoride dihydrate / acetonitrile / Ambient temperature 3: boron trifluoride etherate / CH2Cl2 / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 50 p. 6573 - 6576
反应条件
1: 2.0 g / toluene / Heating 2: 1.) Triton-B; 2.) KOH / 1.) DMF, methanol, r.t., overnight; 2.) aq. methanol, heating, 6 h View Scheme
参考文献
Agricultural and Biological Chemistry, , vol. 49, # 5 p. 1491 - 1496
反应条件
potassium hydroxide; N-benzyl-trimethylammonium hydroxide 1.) DMF, methanol, r.t., overnight; 2.) aq. methanol, heating, 6 h; Yield given. Multistep reaction;
参考文献
Agricultural and Biological Chemistry, , vol. 49, # 5 p. 1491 - 1496
反应条件
zinc(II) chloride Behandeln des Reaktionsprodukts mit wss. Kaliumcarbonat-Loesung;
参考文献
Journal of Organic Chemistry, , vol. 69, # 4 p. 1331 - 1336
