N1,5-二甲基苯-1,2-二胺合成路线 （共 10 条）
反应条件
ethanol; palladium Hydrogenation;
参考文献
Jean-Claude, Bertrand J.; Just, George
Heterocycles, 1998 , vol. 48, # 7 p. 1347 - 1363
反应条件
1: NaOAc / 80 °C 2: H2 / Pd/C / ethanol / 2585.74 Torr View Scheme
参考文献
Seth, Punit P.; Robinson, Dale E.; Jefferson, Elizabeth A.; Swayze, Eric E.
Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7303 - 7306
反应条件
1: 92 percent / 60percent NaH in oil / dimethylformamide / 1 h / 0 °C 2: 2 g / hydrogen / 10percent Pd/C / methanol / 1520 Torr View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
反应条件
1: acetic acid; acetic acid anhydride; nitric acid / und Erhitzen des Reaktionsprodukts mit wss.Schwefelsaeure 2: pyridine 3: aqueous NaOH-solution 4: acetic acid; sulfuric acid 5: palladium; ethanol / Hydrogenation View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
反应条件
zeolite NaY 12 h; Heating;
参考文献
Ebenezer, Warren J.; Hutchings, Michael G.; Jones, Ken; Lambert, David A.; Watt, Ian
Tetrahedron Letters, 2007 , vol. 48, # 9 p. 1641 - 1643
参考文献
Brady; Reynolds
Journal of the Chemical Society, 1928 , p. 198,199
Journal of the Chemical Society, 1931 , p. 1274,1277
反应条件
formic acid in hydrogenchloride; water
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4977175 A1, 1990 ;
反应条件
1: sodium hydrogencarbonate; diethyl ether
2: toluene
View Scheme
参考文献
Green; Day
Journal of the American Chemical Society, 1942 , vol. 64, p. 1167,1170
参考文献
Beaven et al.
Journal of Pharmacy and Pharmacology, 1949 , vol. 1, p. 957,968
反应条件
1: various solvent(s) / 1 h / 130 °C
2: SOCl2 / toluene; dimethylformamide / 2 h / 130 °C
3: acetonitrile / 2 h / 120 °C
4: various solvent(s) / 0.42 h / 220 - 230 °C
View Scheme
参考文献
Loev; Musser; Brown; Jones; Kahen; Huang; Khandwala; Sonnino-Goldman; Leibowitz
Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 363 - 366
