1: 1-(2-deoxy-β-D-erythropentofuranosyl)thymine With pyridine; pivaloyl chloride T=0 - 20°C; 4 h; 2: diphenyl-(4-methoxyphenyl)-methyl chloride T=20°C; 85 h;

1: 1.) imidazole, 2.) pyridine / 1.) DMF, 5 h, 2.) reflux, 2 h 2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: 1.) imidazole, 2.) pyridine / 1.) DMF, 5 h, 2.) reflux, 2 h 2: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / Ambient temperature View Scheme

1: imidazole / dimethylformamide / 3 h / Ambient temperature 2: 80percent acetic acid / 3 h / Ambient temperature View Scheme

zinc dibromide in nitromethane Ambient temperature; Kinetics;

1: 82 percent / 1.)collidine 2.)I2, H2O / tetrahydrofuran 2: 91 percent 3: 25 percent / 1.)Dowex(Py+) 2.)Ph3P-CCl4 4: 76 percent / NaH/CS2 / dimethylformamide 5: 80 percent / 80percent acetic acid 6: ClCN/H2O/collidine / tetrahydrofuran 7: snake venom phosphodiesterase View Scheme