1: With ammonia in water; acetonitrile T=100°C; P=2068.65 Torr; 1 h; 2: With hydrogenchloride; water in acetonitrile pH=4; 3: With sodium hydroxide in diethyl ether; water; acetonitrile pH=14;
参考文献
CEPHALON, INC.; PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2008/51547 A1, 2008 ;
Location in patent: Page/Page column 259; 315 ;
WO 2008/051547 A1