2,N-二甲基-N-甲氧基苯甲酰胺合成路线 （共 9 条）
反应条件
pyridine; carbon tetrabromide; triphenylphosphine in dichloromethane 0.166667 h; Ambient temperature;
参考文献
Einhorn, J.; Einhorn, C.; Luche, J.-L.
Synthetic Communications, 1990 , vol. 20, # 8 p. 1105 - 1112
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With triethylamine in dichloromethane T=0°C; Inert atmosphere; 2: 2-methylbenzoic chloride in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Kishore Kumar; Chavarria, Gustavo E.; Charlton-Sevcik, Amanda K.; Arispe, Wara M.; MacDonough, Matthew T.; Strecker, Tracy E.; Chen, Shen-En; Siim, Bronwyn G.; Chaplin, David J.; Trawick, Mary Lynn; Pinney, Kevin G.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 4 p. 1415 - 1419
反应条件
1: in tetrahydrofuran T=-20°C; 0.0833333 h; Inert atmosphere; 2: With isopropylmagnesium chloride in tetrahydrofuran; diethyl ether T=-20°C; 0.416667 h; Inert atmosphere;
参考文献
Muir, Calum W.; Kennedy, Alan R.; Redmond, Joanna M.; Watson, Allan J. B.
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 20 p. 3337 - 3340
反应条件
4-(N,N-dimethlyamino)pyridine; potassium phosphate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=110°C; Heck reaction; 0.166667 h; Microwave irradiation;
参考文献
Wieckowska, Anna; Fransson, Rebecca; Odell, Luke R.; Larhed, Mats
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 978 - 981
反应条件
1: SOCl2 / toluene; dimethylformamide / 2 h / Heating 2: 1.68 g / pyridine / CH2Cl2 / 20 °C View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
4-(N,N-dimethlyamino)pyridine; potassium phosphate; palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,4-dioxane T=120°C; Heck reaction; 0.666667 h; Microwave irradiation;
参考文献
Wieckowska, Anna; Fransson, Rebecca; Odell, Luke R.; Larhed, Mats
Journal of Organic Chemistry, 2011 , vol. 76, # 3 p. 978 - 981
反应条件
in tetrahydrofuran T=0 - 20°C;
参考文献
Shinagawa, Yuko; Katsushima, Takeo; Nakagawa, Takashi
Patent: US2004/6130 A1, 2004 ;
Location in patent: Page 28 ;
反应条件
in tetrahydrofuran; (2R)-1-[(1R)-(Cyclopropyl)-(2-methylphenyl)methoxy]-3-[[2-methyl-1-(naphthalen-2-yl)propan-2-yl]amino]propan-2-ol
参考文献
Japan Tobacco Inc.
Patent: EP1308436 A1, 2003 ;
反应条件
1: With diisobutylaluminium hydride in tetrahydrofuran; hexane T=-78°C; 1.5 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; hexane; water T=0 - 20°C; Inert atmosphere;
参考文献
Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814
