1: 95 percent / dicyclohexylcarbodiimide, 4-diethylaminopyridine / acetonitrile / 1) 0 deg C, 1 h, 2) 5 deg C, 12 h 2: 92 percent / piperidine / acetonitrile / 12 h / Ambient temperature; or with 1,8-diazobicyclo<5.4.0>undec-7-ene in dioxane View Scheme

1: base 2: 91 percent / piperidine / acetonitrile / Ambient temperature View Scheme

1: DCC, DMAP / acetonitrile / Ambient temperature 2: 62 percent / piperidine / acetonitrile / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '506104', constants.ctx, '0')">ethyl acetate</a> <br />1&nbsp;h;&nbsp;<br /> &nbsp;