4-[4-(4-羟基-3-甲基苯基)己烷-3-基]-2-甲基苯酚合成路线 （共 5 条）
参考文献
Marson,L.M.
Farmaco, Edizione Scientifica, 1964 , vol. 19, p. 543 - 555
参考文献
Gottlieb
Journal of the American Pharmaceutical Association (1912-1977), 1947 , vol. 36, p. 379,381
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Reed and Carnrick
Patent: US2520052 , 1946 ;
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Reed and Carnrick
Patent: US2500855 , 1946 ;
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Niederl et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 508,510
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Reed and Carnrick
Patent: US2419516 , 1944 ;
反应条件
1: 48 percent / ethanol; H2O / 8 h / Heating 2: 1.) Me2SO4, 2.) NaCNBH3 / 1.) ether, RT, 1 h, 2.) HMPA, 120 deg C, 16 h View Scheme
参考文献
Hartmann, Rolf W.; Schwarz, Walter; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1137 - 1144
反应条件
sodium cyanoborohydride; dimethyl sulfate 1.) ether, RT, 1 h, 2.) HMPA, 120 deg C, 16 h; Yield given. Multistep reaction;
参考文献
Hartmann, Rolf W.; Schwarz, Walter; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1137 - 1144
反应条件
1: acetyl chloride 2: ethanol; Raney nickel / 70 °C / Hydrogenation 3: aqueous methanol. KOH View Scheme
参考文献
Reed and Carnrick
Patent: US2520052 , 1946 ;
