S-(三氟甲基)二苯并噻吩三氟甲基磺酸盐合成路线 （共 67 条）
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in N,N-dimethyl-formamide
T=0°C; 1 h;
2: With hydrogenchloride; water
2 h;
参考文献
MERCK and CO., INC.; MERCK SHARP and DOHME LIMITED
Patent: WO2003/93266 A1, 2003 ;
Location in patent: Page/Page column 21-22 ;
WO 03/093266 A1
反应条件
2,4,6-trimethyl-pyridine; copper diacetate in N,N-dimethyl acetamide
T=20°C; 20 h; Inert atmosphere;
参考文献
Xu, Jun; Luo, Dong-Fen; Xiao, Bin; Liu, Zhao-Jing; Gong, Tian-Jun; Fu, Yao; Liu, Lei
Chemical Communications, 2011 , vol. 47, # 14 p. 4300 - 4302
反应条件
2,6-di-tert-butyl-4-methylpyridine in 1,2-dichloro-ethane
T=20°C; 20 h; Inert atmosphere;
参考文献
Xu, Jun; Luo, Dong-Fen; Xiao, Bin; Liu, Zhao-Jing; Gong, Tian-Jun; Fu, Yao; Liu, Lei
Chemical Communications, 2011 , vol. 47, # 14 p. 4300 - 4302
反应条件
2,4,6-trimethyl-pyridine in N,N-dimethyl acetamide
T=20°C; 20 h; Inert atmosphere;
参考文献
Xu, Jun; Luo, Dong-Fen; Xiao, Bin; Liu, Zhao-Jing; Gong, Tian-Jun; Fu, Yao; Liu, Lei
Chemical Communications, 2011 , vol. 47, # 14 p. 4300 - 4302
反应条件
(2R,6S)-2,6-dimethylpiperidine in 1,2-dichloro-ethane
T=20°C; 20 h; Inert atmosphere;
参考文献
Xu, Jun; Luo, Dong-Fen; Xiao, Bin; Liu, Zhao-Jing; Gong, Tian-Jun; Fu, Yao; Liu, Lei
Chemical Communications, 2011 , vol. 47, # 14 p. 4300 - 4302
反应条件
copper in N,N-dimethyl-formamide
T=60°C; 11 h; Inert atmosphere;
参考文献
Kawai, Hiroyuki; Furukawa, Tatsuya; Nomura, Yoshinori; Tokunaga, Etsuko; Shibata, Norio
Organic Letters, 2011 , vol. 13, # 14 p. 3596 - 3599
反应条件
copper in acetonitrile
T=60°C; 9 h; Inert atmosphere;
参考文献
Zhu, Lingui; Liu, Shasha; Douglas, Justin T.; Altman, Ryan A.
Chemistry - A European Journal, 2013 , vol. 19, # 38 p. 12800 - 12805
