3-氯-2-氟-5-(三氟甲基)苯甲酸合成路线 (共 5 条)
反应条件
1: 3-chloro-4-fluoro-α,α,α-trifluorotoluene With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - -73°C; 1.41667 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - -75°C; 1 h; 3: With hydrogenchloride; water in tetrahydrofuran; hexane T=-4°C; 0.5 h; Product distribution / selectivity;
参考文献
Bachmann, Stephan; Hildbrand, Stefan; Jappy, James; Patel, Dinesh Maganbhai; Pfleger, Christophe; Tidswell, Robert John Ernest; Trussardi, Rene
Patent: US2009/306423 A1, 2009 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogenchloride; nitrogen in diethyl ether; pentane
参考文献
Occidental Chemical Corporation
Patent: US5196593 A1, 1993 ;
反应条件
1: With potassium permanganate in water; acetone 0.5 h; 2: With hydrogenchloride in water pH=1; Product distribution / selectivity;
参考文献
Bachmann, Stephan; Hildbrand, Stefan; Jappy, James; Patel, Dinesh Maganbhai; Pfleger, Christophe; Tidswell, Robert John Ernest; Trussardi, Rene
Patent: US2009/306423 A1, 2009 ;
Location in patent: Page/Page column 7-8 ;
反应条件
thionyl chloride in N-methyl-acetamide
参考文献
Occidental Chemical Corporation
Patent: US5196593 A1, 1993 ;
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in toluene T=20°C; 0.5 h; Inert atmosphere; Product distribution / selectivity;
参考文献
WO2011/157670 A2, ;
Page/Page column 37-38 ;