(+/-)-4-N-Boc-2-哌嗪甲酸甲酯合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; 3 h;
参考文献
ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A.; BRANCA, Danila; FERRIGNO, Federica; HERNANDO, Jose, Ignacio, Martin; JONES, Philip; KINZEL, Olaf; MALANCONA, Savina; MURAGLIA, Ester; PALUMBI, Maria, Cecilia; PESCATORE, Giovanna; SCARPELLI, Rita
Patent: WO2010/23480 A1, 2010 ;
Location in patent: Page/Page column 44 ;
反应条件
triethylamine in dichloromethane
反应条件
1: aq. NaOH / dioxane 2: dioxane 3: tetrahydrofuran 4: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: aq. NaOH / dioxane 2: dioxane 3: tetrahydrofuran 4: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: piperazine-1,3-dicarboxylic acid 1-tert-butyl ester With caesium carbonate in water; N,N-dimethyl-formamide T=20 - 45°C; 2: methyl iodide in N,N-dimethyl-formamide T=60°C;
参考文献
Wu, Guosheng; Zhao, Hua; Luo, Robert G.; Wei, Dean; Malhotra, Sanjay V.
Enantiomer, 2001 , vol. 6, # 6 p. 343 - 345
反应条件
1: tetrahydrofuran 2: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: dioxane 2: tetrahydrofuran 3: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 23 p. 4241 - 4244
反应条件
1: H2, aq. NaOH / 20 percent Pd/C 2: tetrahydrofuran 3: dioxane; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 8 p. 1121 - 1126
反应条件
in 1,4-dioxane; water
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 8 p. 1121 - 1126
反应条件
lipase A from candida antarctica immobilized on Celite in tert-butyl methyl ether Enzymatic reaction; optical yield given as percent ee;
参考文献
Arkivoc, , vol. 2012, # 5 p. 60 - 74
