N-Boc-3-氨基-3-甲基丁酸合成路线 （共 18 条）
反应条件
1: With potassium hydroxide in 1,4-dioxane; water T=20°C; 16 h; 2: With hydrogenchloride in water pH=3;
参考文献
US2010/204274 A1, ;
Page/Page column 30 ;
US 20100204274 A1
反应条件
lithium hydroxide in tetrahydrofuran T=0 - 5°C; 2 h;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 7 p. 897 - 906
反应条件
in tetrahydrofuran; hexane; water
反应条件
potassium hydroxide in tetrahydrofuran 18 h;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 633 - 642
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 1 p. 373 - 380
反应条件
1: Et3N / dioxane 2: KOCl / dioxane; H2O View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1274 - 1279
反应条件
1: NH3 / H2O / 18 h / 150 °C 2: 1.) NaOH / 1.) H2O, reflux, 24 h; 2.) H2O, dioxane, RT, 12 h View Scheme
参考文献
Helvetica Chimica Acta, , vol. 81, # 12 p. 2218 - 2243
反应条件
1: triethylamine, DMPA / CH2Cl2 / Ambient temperature 2: 87 percent / 1.0 M aq. lithium hydroxide / tetrahydrofuran / 2 h / 0 - 5 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 7 p. 897 - 906
反应条件
1: 89 percent / NH3(gas) / ethanol / 22 h / 80 °C 2: 81 percent / CH2Cl2 / 18 h 3: 82 percent / aq. KOH / tetrahydrofuran / 18 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 633 - 642
反应条件
1: 81 percent / CH2Cl2 / 18 h 2: 82 percent / aq. KOH / tetrahydrofuran / 18 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 633 - 642
