(S)-(-)-1,1,1-三氟-2-辛醇合成路线 (共 7 条)
反应条件
B-chloro-diisopinocampheylborane in diethyl ether T=-25°C; 8 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 6 p. 1075 - 1086
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran
参考文献
Ramachandran, P. Veeraraghavan; Teodorovic, Aleksandar V.; Gong, Baoqing; Brown, Herbert C.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1075 - 1086
反应条件
2-(n-morpholino)ethanesulfonic acid; 1-hydroxycyclopentane; alcohol dehydrogenase from Geotrichum candidum (APG4); nicotinamide adenine dinucleotide T=30°C; 20 h; pH=7.0; Yield given;
参考文献
Tetrahedron Letters, , vol. 37, # 32 p. 5727 - 5730
反应条件
vinyl acetate in hexane; water T=50°C; Resolution of racemateEnzymatic reaction; Reagent/catalystSolventTemperature; enantioselective reaction;
参考文献
RSC Advances, , vol. 4, # 12 p. 6103 - 6109
反应条件
copper(l) iodide in tetrahydrofuran; diethyl ether 1.) -20 to 25 deg C, 2.) 25 deg C, 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 60, # 1 p. 41 - 46
反应条件
1: 78 percent / diethyl ether; hexane / 1.5 h / -78 °C 2: (-)-diisopinocampheylchloroborane / diethyl ether / 8 h / -25 °C View Scheme
参考文献
Tetrahedron: Asymmetry, , vol. 5, # 6 p. 1075 - 1086
反应条件
hydrogenchloride; N,N-di-methylaminopyridine; triethylamine in dichloromethane