trichlorophosphate in acetonitrile T=80°C; Vilsmeier-Haack reaction; 3 h;

potassium tert-butylate in tetrahydrofuran T=0°C; diastereoselective reaction;

1: 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 48 h / 35 °C 2: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C 3: trichlorophosphate / acetonitrile / 3 h / 80 °C View Scheme

1: 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 48 h / 35 °C 2: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C 3: trichlorophosphate / acetonitrile / 3 h / 80 °C View Scheme

1: 2,6-di-tert-butyl-pyridine; copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 48 h / 35 °C 2: trichlorophosphate / acetonitrile / 3 h / 80 °C View Scheme

1: sodium hydride / N,N-dimethyl-formamide / 3 h / 20 °C 2: trichlorophosphate / acetonitrile / 3 h / 80 °C View Scheme