5 -甲氧基-3,4二氢- 1(2H)-异喹啉合成路线 （共 8 条）
反应条件
hydrogenchloride; sodium azide in water T=0 - 20°C;
参考文献
Abate, Carmen; Selivanova, Svetlana V.; Mueller, Adrienne; Kraemer, Stefanie D.; Schibli, Roger; Marottoli, Roberta; Perrone, Roberto; Berardi, Francesco; Niso, Mauro; Ametamey, Simon M.
European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 920 - 930
反应条件
1: 3,4-dihydro-5-hydroxy-1(2H)-isoquinolinone With caesium carbonate in N,N-dimethyl-formamide T=50°C; 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide T=50°C; 0.5 h;
参考文献
WO2011/92293 A2, ;
Page/Page column 91 ;
WO 2011/092293 A1
反应条件
sodium hydroxide in acetone T=20°C; Etherification; 3 h;
参考文献
Miyake, Yoshinori; Shimadzu, Hiroshi; Hashimoto, Naoto; Ishida, Yoshio; Shibakawa, Masahiko; Nishimura, Tsunehiko
Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 10 p. 983 - 988
反应条件
dimethyl sulfate in methanol; sodium hydroxide; water
参考文献
Warner-Lambert Company
Patent: US5177075 A1, 1993 ;
反应条件
PPA T=145°C; Cyclization; 0.166667 h;
参考文献
Perrone, Roberto; Berardi, Francesco; Colabufo, Nicola A.; Leopoldo, Marcello; Tortorella, Vincenzo
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 270 - 277
反应条件
1: 100 percent / Et3N / tetrahydrofuran / 24 h / 20 °C 2: 22 percent / polyphosphoric acid / 0.17 h / 145 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 2 p. 270 - 277
反应条件
bismuth trifluoromethanesulphonate T=100 - 120°C; Beckmann rearrangement; 0.5 h;
参考文献
Torisawa, Yasuhiro; Nishi, Takao; Minamikawa, Jun-Ichi
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 3 p. 387 - 390
反应条件
1: potassium carbonate / acetone / 6 h / |Reflux 2: hydrogenchloride; sodium azide / water / 0 - 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 920 - 930
