3-[(1H-吡咯-2-羰基)-氨基]丙酸合成路线 （共 7 条）
反应条件
sodium hydroxide T=60 - 70°C; 1 h;
参考文献
Kasum, Bruno; Prager, Rolf H.; Tsopelas, Chris
Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 355 - 365
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran 4 h;
参考文献
Mizuno, Akira; Inomata, Norio; Miya, Mikiko; Kamei, Tomoe; Shibata, Makoto; Tatsuoka, Toshio; Yoshida, Maki; Takiguchi, Chikako; Miyazaki, Tomoko
Chemical and Pharmaceutical Bulletin, 1999 , vol. 47, # 2 p. 246 - 256
反应条件
1: 97 percent / triethylamine / acetonitrile / 48 h / 20 °C 2: 98 percent / NaOH / H2O / 18 h / 20 °C View Scheme
参考文献
White, Alex W.; Carpenter, Nicholas; Lottin, Jerome R. P.; McClelland, Richard A.; Nicholson, Robert I.
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 246 - 253,8
反应条件
1: 89 percent / diethyl phosphorocyanidate, Et3N / dimethylformamide / 20 h / Ambient temperature 2: 84 percent / H2 / 5 percent Pd/C / tetrahydrofuran / 4 h View Scheme
参考文献
Kasum, Bruno; Prager, Rolf H.; Tsopelas, Chris
Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 355 - 365
反应条件
sodium hydroxide in ethanol 18 h; Ambient temperature;
参考文献
Cho, Hidetsura; Matsuki, Shinsuke; Mizuno, Akira; Annoura, Hirokazu; Tatsuoka, Toshio
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 1 p. 87 - 91
反应条件
1: 1.) Et3N / 1.) CH2Cl2, RT, 30 min, 2.) CH2Cl2, toluene, 0 deg C, 1 h 2: 50 percent / 3.75 N NaOH / ethanol / 18 h / Ambient temperature View Scheme
参考文献
Annoura, Hirokazu; Tatsuoka, Toshio
Tetrahedron Letters, 1995 , vol. 36, # 3 p. 413 - 416
反应条件
PPA; phosphorus pentoxide
T=118 - 120°C; 0.5 h;
参考文献
Kasum, Bruno; Prager, Rolf H.; Tsopelas, Chris
Australian Journal of Chemistry, 1990 , vol. 43, # 2 p. 355 - 365
