2-乙基-5-三氟甲基-2H-吡唑-3-羧酸合成路线 (共 2 条)
反应条件
1: 3-(trifluoromethyl)-1H-pyrazole; ethyl iodide With potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 2: With n-butyllithium in tetrahydrofuran T=-78°C; 0.333333 h; Cooling with acetone-dry iceNitrogen atmosphere; 3: carbon dioxide With hydrogenchloride more than 3 stages;
参考文献
US2003/229050 A1, ;
Page 25 ;
反应条件
1: 1-ethyl-3-(trifluoromethyl)-1H-pyrazole With lithium diisopropyl amide in tetrahydrofuran T=-78°C; 2: carbon dioxide in tetrahydrofuran
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 22 p. 4898 - 4906