2-氧代-5,6-二氢吡啶-1(2H)-羧酸叔丁酯合成路线 （共 6 条）
反应条件
dihydrogen peroxide in tetrahydrofuran T=0 - 20°C; 0.75 h;
参考文献
TOLERO PHARMACEUTICALS, INC.; XU, Yong; BRENNING, Benjamin, Gary; KULTGEN, Steven, G.; LIU, Xiaohui; SAUNDERS, Michael; HO, Koc-Kan
Patent: WO2013/13188 A1, 2013 ;
Location in patent: Paragraph 00333 ;
WO 2013/013188 A1
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.166667 h; 2: in tetrahydrofuran; hexane T=-78°C; 0.5 h; Further stages.;
参考文献
Garnier, Ethel C.; Liebeskind, Lanny S.
Journal of the American Chemical Society, 2008 , vol. 130, # 23 p. 7449 - 7458
反应条件
p-benozquinone; Pd-catalyst in acetonitrile T=20°C;
参考文献
SIEGFRIED GENERICS INTERNATIONAL AG
Patent: WO2005/7618 A1, 2005 ;
Location in patent: Page/Page column 14; 15 ;
反应条件
1: TEA; DMAP / CH2Cl2 / 0 - 20 °C 2: LDA; HMPA / tetrahydrofuran / -78 °C 3: m-CPBA / CH2Cl2 4: toluene / 80 °C View Scheme
参考文献
Li, Xiaoyuan; Huang, Ping; Cui, Jingrong Jean; Zhang, Jennifer; Tang, Cho
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 11 p. 1939 - 1942
反应条件
1: TEA; DMAP / CH2Cl2 / 0 - 20 °C 2: LDA; HMPA / tetrahydrofuran / -78 °C 3: m-CPBA / CH2Cl2 4: toluene / 80 °C View Scheme
参考文献
Li, Xiaoyuan; Huang, Ping; Cui, Jingrong Jean; Zhang, Jennifer; Tang, Cho
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 11 p. 1939 - 1942
反应条件
trifluoroacetic acid in dichloromethane T=20°C; Inert atmosphere;
参考文献
Winter, Dana K.; Drouin, Alexandre; Lessard, Jean; Spino, Claude
Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2610 - 2618
