5-硝基-1H-吲哚-3-羧酰胺合成路线 （共 5 条）
反应条件
in tetrahydrofuran; 1,2-dichloro-ethane
参考文献
Merck Sharp and Dohme Limited
Patent: US4940703 A1, 1990 ;
反应条件
ammonia in 1,2-dichloro-ethane Yield given;
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
反应条件
1: 1.) trifluoroacetic anhydride (TFAA), 2.) aq. NaOH / 1.) reflux, 24 h 2: oxalyl chloride / tetrahydrofuran / 24 h / Ambient temperature 3: NH3 gas / 1,2-dichloro-ethane View Scheme
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
反应条件
1: oxalyl chloride / tetrahydrofuran / 24 h / Ambient temperature 2: NH3 gas / 1,2-dichloro-ethane View Scheme
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
反应条件
triethylamine; trifluoroacetic anhydride in 1,4-dioxane Ambient temperature;
参考文献
Swain; Baker; Kneen; Herbert; Moseley; Saunders; Seward; Stevenson; Beer; Stanton; Watling; Ball
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1019 - 1031
