1: CF3COOH / CH2Cl2 2: acetone / 35 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 99 percent / H₂ / 10percent Pd/C / methanol / 3 h / 2275.5 Torr<br />2: 17 percent / potassium tert-butoxide / CH₂Cl₂ / 4 h / -78 - 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 52 percent / N-methylmorpholine, 1-hydroxybenzotriazole (HOBt), 1-&lt;3-(dimethylamino)propyl&gt;-3-ethylcarbodiimide hydrochloride (EDC) / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight<br />2: 99 percent / H₂ / 10percent Pd/C / methanol / 3 h / 2275.5 Torr<br />3: 17 percent / potassium tert-butoxide / CH₂Cl₂ / 4 h / -78 - 20 &deg;C<br /> <br /> &nbsp;