1,2-双(甲基磺酰基)-1-(2-氯乙基)肼合成路线 （共 4 条）
反应条件
lithium chloride in N,N-dimethyl-formamide T=60°C; 24 h;
参考文献
Nanotherapeutics, Inc.
Patent: US8026395 B1, 2011 ;
Location in patent: Page/Page column 5 ;
反应条件
water in aq. buffer T=40°C; pH=7.4; 1 h;
参考文献
Zhu, Rui; Baumann, Raymond P.; Patridge, Eric; Penketh, Philip G.; Shyam, Krishnamurthy; Ishiguro, Kimiko; Sartorelli, Alan C.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1853 - 1859
反应条件
1: phosgene; 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine With N-ethyl-N,N-diisopropylamine in toluene; acetonitrile T=-15 - 0°C; 0.5 h; 2: methylamine With N-ethyl-N,N-diisopropylamine in tetrahydrofuran; toluene; acetonitrile T=0 - 20°C; 2.5 h;
参考文献
Nanotherapeutics, Inc.
Patent: US8026395 B1, 2011 ;
Location in patent: Page/Page column 6-7 ;
反应条件
triethylamine in acetonitrile Ambient temperature;
参考文献
Shyam, Krishnamurthy; Penketh, Philip G.; Loomis, Regina H.; Rose, William C.; Sartorelli, Alan C.
J. Med. Chem., 1996 , vol. 39, # 3 p. 796 - 801
