hydrogenchloride in ethyl acetate 1.) 0 deg C, 15 min, 2.) RT, 30 min;

1: 67.2 percent / N,N-diisopropylethylamine / tetrahydrofuran 2: 74.8 percent / aq. NaOH / toluene / 21 h / 0 - 20 °C 3: 1.) LiH / 1.) hexane, 2.) hexane, 60 deg C, 25 h 4: 39.6 percent / HMPA / 72 h / Ambient temperature 5: 97.4 percent / HCl (gas) / ethyl acetate / 1.) 0 deg C, 15 min, 2.) RT, 30 min View Scheme

1: 74.8 percent / aq. NaOH / toluene / 21 h / 0 - 20 °C 2: 1.) LiH / 1.) hexane, 2.) hexane, 60 deg C, 25 h 3: 39.6 percent / HMPA / 72 h / Ambient temperature 4: 97.4 percent / HCl (gas) / ethyl acetate / 1.) 0 deg C, 15 min, 2.) RT, 30 min View Scheme