4-乙酰氨基-5-氯-2-甲氧基-3-硝基苯甲酸甲酯合成路线 （共 5 条）
反应条件
nitric acid T=-35 - -30°C; 0.166667 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 3 p. 560 - 569
反应条件
1: thionyl chloride / 5 h / 80 °C 2: acetic acid / 5 h / 50 °C 3: nitric acid / 0.42 h / 20 °C View Scheme
参考文献
US2012/277224 A1, ;
US 20120277224 A1
反应条件
1: acetic acid / 5 h / 50 °C 2: nitric acid / 0.42 h / 20 °C View Scheme
参考文献
US2012/277224 A1, ;
US 20120277224 A1
反应条件
1: With sulfuric acid in methanol
7 h; Reflux;
2: With sodium hydrogencarbonate in water
参考文献
InterMune, Inc.
Patent: US2011/152246 A1, 2011 ;
Location in patent: Page/Page column 193 ;
反应条件
1: 94 percent / aq. H2SO4 / methanol / 9 h / Heating
2: H2; Et3N / Pd/C / 6 h / 3800 Torr
View Scheme
参考文献
Renneberg, Dorte; Dervan, Peter B.
Journal of the American Chemical Society, 2003 , vol. 125, # 19 p. 5707 - 5716
