2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: 97 percent / p-TsOH / benzene / 19 h / Heating 2: 1.) NaNH2, 2.) NH4Cl / 1.) NH3, Et2O 3: 1.) BuLi / 1.) THF, HMPA, hexane, -72 deg C, 15 min, 2.) THF, hexane, HMPA, , -55 - -50 deg C, 20 min; rt, 1 h 4: t-BuOK / dimethylsulfoxide; diethyl ether / -23 - 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 5 p. 1694 - 1703
反应条件
1: para-bromotoluene With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tBuCH2CH2B(H)NiPr2; triethylamine; triphenylphosphine in tetrahydrofuran T=65°C; Alcaraz-Vaultier borylation; 12 h; Inert atmosphere; 2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran T=0 - 25°C; 0.25 h; Inert atmosphere; Further stages;
参考文献
Tetrahedron, , vol. 67, # 3 p. 576 - 583
反应条件
1: 1-(iodo)-4-methylbenzene With tBuCH2CH2B(H)NiPr2; triethylamine; triphenylphosphine; palladium dichloride in tetrahydrofuran T=65°C; Alcaraz-Vaultier borylation; 12 h; Inert atmosphere; 2: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran T=0 - 25°C; 0.25 h; Inert atmosphere; Further stages;
参考文献
Tetrahedron, , vol. 67, # 3 p. 576 - 583
反应条件
1: Sb(o-tolyl)3 With boron trichloride in dichloromethane T=0°C; 2 h; 2: With methanol T=20°C; 0.5 h; 3: 3-hydroxy-2,2-dimethylpropanol in methanol T=20°C; 1 h;
参考文献
Chemistry Letters, , vol. 35, # 12 p. 1402 - 1403
反应条件
1: in cyclohexane 1.5 h; Heating / reflux; 2: With N-bromosuccinmide; dibenzoyl peroxide in cyclohexane 2 h; Heating / reflux;
参考文献
US2007/117983 A1, ;
Page/Page column 13 ;
反应条件
in tetrahydrofuran 0.666667 h; Dean-StarkReflux;
参考文献
Advanced Synthesis and Catalysis, , vol. 356, # 7 p. 1527 - 1532
参考文献
The Journal of organic chemistry, , vol. 68, # 13 p. 5168 - 5173
反应条件
in dichloromethane all reactions under Ar atm.; soln. of BCl3 in CH2Cl2 added to stirred soln. of triarylstibane at 0°C, stirred for 2 h, allowed to warm toroom temp., solvent removed in vac., oil dissolved in MeOH, stirred for 30 min at room temp., diol added; stirred for 1 h, solvent removed in vac., chromy. (silica-gel, hexane/CH2Cl2);
参考文献
Chemistry Letters, , vol. 35, # 12 p. 1402 - 1403
反应条件
1: potassium acetate / 80 °C 2: tetrakis(triphenylphosphine) palladium(0) / toluene / 24 h / 80 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 53, # 46 p. 6230 - 6235,6
反应条件
1: 96 percent / pyridine 2: 71 percent / ethane-1,2-diol / 2 h / Heating 3: 85 percent / NaOH / H2O / 48 h / Heating 4: 89 percent / Thionyl chloride 5: 98 percent / NH3 / diethyl ether / 2 h View Scheme
参考文献
Wills, Max T.; Wills, Irene E.; Dollen, Lawrence Von; Butler, Barry L.; Porter, John; Anderson, Arthur G.
Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2489 - 2498
