2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: With toluene-4-sulfonic acid in toluene
T=110°C; 1 h; Inert atmosphere;
2: With diisobutylaluminium hydride in hexane; dichloromethane
T=-78°C; 2 h; Inert atmosphere;
参考文献
Yang, Dexi; Micalizio, Glenn C.
Journal of the American Chemical Society, 2011 , vol. 133, # 24 p. 9216 - 9219
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 20°C;
参考文献
Jandeleit, Bernd; Li, Yunxiao; Gallop, Mark A.; Zerangue, Noa; Virsik, Peter A.; Fischer, Wolf-Nicolas
Patent: US2009/82464 A1, 2009 ;
Location in patent: Page/Page column 44-45 ;
反应条件
in chlorobenzene
20 h; Heating;
参考文献
Schlachter, Stephen T.; Galinet, Louise A.; Shields, Sharon K.; Aspar, Danielle G.; Dunn, Colin J.; Staite, Nigel D.; Nugent, Richard A.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 9 p. 1093 - 1096
反应条件
1: TsOH / benzene / Heating
2: H2, Et3N / Pd-C
3: aq. NaHCO3, I2, KI / methanol
View Scheme
参考文献
Hudson,M.F.; Smith,K.M.
Synthesis, 1976 , p. 464 - 467
反应条件
1: TsOH / benzene / Heating
2: H2, Et3N / Pd-C
3: aq. NaHCO3, I2, KI / methanol
4: H2, Et3N / PtO2 / methanol
View Scheme
参考文献
Hudson,M.F.; Smith,K.M.
Synthesis, 1976 , p. 464 - 467
反应条件
in diethyl ether
T=20°C; Inert atmosphere;
参考文献
Pulis, Alexander P.; Blair, Daniel J.; Torres, Eva; Aggarwal, Varinder K.
Journal of the American Chemical Society, 2013 , vol. 135, # 43 p. 16054 - 16057
参考文献
Kuznetsov,V.V. et al.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1978 , vol. 14, p. 19 - 22
Khimiya Geterotsiklicheskikh Soedinenii, 1978 , vol. 14, # 1 p. 26 - 30
反应条件
toluene-4-sulfonic acid; sodium sulfate in water; benzene
4 h; Heating / reflux;
参考文献
Balakumar, Arumugham; Muthukumaran, Kannan; Lindsey, Jonathan S.
Patent: US2005/277770 A1, 2005 ;
Location in patent: Page/Page column 8-9 ;
参考文献
Societe Francaise Hoechst
Patent: US4835320 A1, 1989 ;
反应条件
toluene-4-sulfonic acid in benzene
4 h; Heating;
参考文献
Balakumar, Arumugham; Muthukumaran, Kannan; Lindsey, Jonathan S.
Journal of Organic Chemistry, 2004 , vol. 69, # 15 p. 5112 - 5115
