2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
toluene-4-sulfonic acid in toluene
Inert atmosphereReflux;
参考文献
Tewes, Bastian; Frehland, Bastian; Schepmann, Dirk; Schmidtke, Kai-Uwe; Winckler, Thomas; Wuensch, Bernhard
ChemMedChem, 2010 , vol. 5, # 5 p. 687 - 695
反应条件
sodium hydride in tetrahydrofuran
T=63°C; 0.5 h;
参考文献
Toivonen, Hannu
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 1 p. 37 - 42
反应条件
toluene-4-sulfonic acid in phosphorus tribromide; 1,3-dichloroethane
参考文献
Bartels; Gunter
Patent: US4847391 A1, 1989 ;
反应条件
in diethyl ether
T=20°C; Inert atmosphere;
参考文献
Pulis, Alexander P.; Blair, Daniel J.; Torres, Eva; Aggarwal, Varinder K.
Journal of the American Chemical Society, 2013 , vol. 135, # 43 p. 16054 - 16057
反应条件
in toluene
RefluxInert atmosphere;
参考文献
Berini, Christophe; Navarro, Oscar
Chemical Communications, 2012 , vol. 48, # 10 p. 1538 - 1540
反应条件
n-butyllithium; magnesium sulfate in tetrahydrofuran
n-BuLi added to soln. of BrC6H4SiMe3 in THF at -78°C; after 15 min B(OiPr)3 added dropwise; warmed to room temp. overnight; H2O, Et2O, concd. HCl added; org. phase washed (H2O, brine); solvent removed (vac.); residue dissolved in THF;; neopentyl glycol and MgSO4 added; stirred for 1 h; solvent removed (vac.); hexane added to the oily residue; filtered; crystn. from filtrate at -25°C; elem. anal.;
参考文献
Deeg, Oliver; Baeurle, Peter
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 9 p. 1609 - 1624
反应条件
sodium hydroxide
T=220°C; 5 h; Autoclave;
参考文献
Krysin; Pustovskikh; Koptyug
Russian Journal of General Chemistry, 2010 , vol. 80, # 10 p. 2001 - 2006
反应条件
toluene-4-sulfonic acid
0.5 h;
参考文献
Sant, Milind P.; Smith, William B.
Journal of Organic Chemistry, 1993 , vol. 58, # 20 p. 5479 - 5481
反应条件
1: alpha-Terthiophene With n-butyllithium in tetrahydrofuran; hexane
T=-40°C; 1 h;
2: With tributoxyborane in tetrahydrofuran; hexane
T=-90°C; 1 h;
3: 3-hydroxy-2,2-dimethylpropanol in tetrahydrofuran; hexane
T=20°C; 0.25 h; Further stages.;
参考文献
Frigoli, Michel; Moustrou, Corinne; Samat, Andre; Guglielmetti, Robert
European Journal of Organic Chemistry, 2003 , # 15 p. 2799 - 2812
反应条件
in toluene
T=20°C; 2 h;
参考文献
NOVO NORDISK A/S
Patent: WO2003/105860 A1, 2003 ;
Location in patent: Page 30 ;
WO 03/105860 A1
