2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: 3-hydroxy-2,2-dimethylpropanol With sodium hydride in tetrahydrofuran
T=20°C; 1.5 h; Inert atmosphereReflux;
2: allyl bromide in tetrahydrofuran
T=20°C; 9 h; Inert atmosphereReflux;
参考文献
Ting, Chun-Ming; Wang, Chiou-Dong; Chaudhuri, Rupsha; Liu, Rai-Shung
Organic Letters, 2011 , vol. 13, # 7 p. 1702 - 1705
反应条件
sodium hydride in tetrahydrofuran
T=63°C; 0.5 h;
参考文献
Toivonen, Hannu
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1984 , vol. 38, # 1 p. 37 - 42
反应条件
sodium hydride
1) THF, 30 min, r.t., 2) THF, 6 h, reflux; Yield given. Multistep reaction;
参考文献
Weber, Edwin
Chemische Berichte, 1981 , vol. 114, # 4 p. 1551 - 1553
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 20°C;
参考文献
Jandeleit, Bernd; Li, Yunxiao; Gallop, Mark A.; Zerangue, Noa; Virsik, Peter A.; Fischer, Wolf-Nicolas
Patent: US2009/82464 A1, 2009 ;
Location in patent: Page/Page column 45 ;
反应条件
1: in dichloromethane
T=20°C; 0.5 h; Inert atmosphere;
2: With water; sodium hydrogencarbonate in dichloromethane
Saturated solution; chemoselective reaction;
参考文献
Wakita, Natsumi; Hara, Shoji
Tetrahedron, 2010 , vol. 66, # 40 p. 7939 - 7945
反应条件
1.1: 1.5 h / 0 °C / |Inert atmosphere
1.2: |Cooling with ice; |Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / 20 °C / |Cooling with acetone-dry ice; |Inert atmosphere
2.2: 0 - 20 °C
View Scheme
参考文献
Elliott, Mark C.; Smith, Keith; Heulyn Jones; Hussain, Ajaz; Saleh, Basil A.
Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3057 - 3064
反应条件
pyridinium p-toluenesulfonate in toluene
参考文献
Deagostino, Annamaria; Prandi, Cristina; Venturello, Paolo
Synthesis, 1998 , # 8 p. 1149 - 1152
反应条件
1.1: p-toluenesulfonic acid / benzene / 5 h / Heating
2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -70 °C
2.2: tetrahydrofuran; hexane / -70 - 20 °C
3.1: p-toluenesulfonic acid / benzene / 2 h / Heating
View Scheme
参考文献
Krebs, Frederik C.; Jorgensen, Mikkel
Macromolecules, 2003 , vol. 36, # 12 p. 4374 - 4384
反应条件
toluene-4-sulfonic acid in benzene
2 h; Heating;
参考文献
Krebs, Frederik C.; Jorgensen, Mikkel
Macromolecules, 2003 , vol. 36, # 12 p. 4374 - 4384
反应条件
toluene-4-sulfonic acid in benzene
参考文献
Imperial Chemical Industries PLC
Patent: US4533656 A1, 1985 ;
