2,2-二甲基-1,3-丙二醇合成路线 （共 467 条）
反应条件
1: 2,2,6,6-tetramethyl-piperidine With n-butyllithium in tetrahydrofuran; hexane
T=-10°C; 0.166667 h;
2: tri-isopropoxy-borane; alpha-chloronaphthalene in tetrahydrofuran; hexane
T=-78 - 20°C;
3: 3-hydroxy-2,2-dimethylpropanol With acetic acid in tetrahydrofuran; hexane
T=20°C; 1 h; Further stages.;
参考文献
Lysen, Morten; Madden, Maurice; Kristensen, Jesper Langgaard; Vedso, Per; Zoellner, Camilla; Begtrup, Mikael
Synthesis, 2006 , # 20 p. 3478 - 3484
反应条件
acetic acid in tetrahydrofuran; hexane
T=20°C; 1 h;
参考文献
Lysen, Morten; Madden, Maurice; Kristensen, Jesper Langgaard; Vedso, Per; Zoellner, Camilla; Begtrup, Mikael
Synthesis, 2006 , # 20 p. 3478 - 3484
参考文献
Jiang, Qian; Zhang, Zhanyuan; Lu, Jiao; Huang, Yan; Lu, Zhiyun; Tan, Yanfei; Jiang, Qing
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 24 p. 7735 - 7741
反应条件
1: t-BuOK / 2-methyl-propan-2-ol / Heating
2: TsOH / Heating
3: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Kitazawa, Sadaya; Kimura, Keiichi; Yano, Hideki; Shono, Toshiyuki
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 6978 - 6983
反应条件
1: NaH; Bu4NI / tetrahydrofuran / 0 °C
2: (COCl)2; DMSO; Et3N / CH2Cl2 / -78 °C
View Scheme
参考文献
Trieselmann, Thomas; Hoffmann, Reinhard W.; Menzel, Karsten
European Journal of Organic Chemistry, 2002 , # 7 p. 1292 - 1304
反应条件
1: 82 percent / conc. nitric acid / H2O
2: 1.) thionyl chloride / 1.) THF, reflux, 2 h; 2.) ether, ice-cooling
3: 35 percent / phosphorus pentaoxide / xylene / 2 h / Heating
4: 72 percent / acetic anhydride, conc. sulphuric acid, H2 / Pd/C / acetic acid / 12 h / Ambient temperature
View Scheme
参考文献
Evans, Andrew R.; Martin, Russell; Taylor, Giles A.; Yap, C. H. Maurice
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1635 - 1640
参考文献
Takaya, Jun; Tadami, Satoshi; Ukai, Kazutoshi; Iwasawa, Nobuharu
Organic Letters, 2008 , vol. 10, # 13 p. 2697 - 2700
反应条件
(i) DMSO, NaOH, (ii) /BRN= 1730909/; Multistep reaction;
参考文献
Smith,R.G. et al.
Canadian Journal of Chemistry, 1969 , vol. 47, p. 2015 - 2019
反应条件
1: tri(.alpha.-naphthyl)antimony(III) With boron trichloride in dichloromethane
T=0°C; 2 h;
2: With methanol
T=20°C; 0.5 h;
3: 3-hydroxy-2,2-dimethylpropanol in methanol
T=20°C; 1 h;
参考文献
Yasuike, Shuji; Nakata, Kazuhide; Qin, Weiwei; Kaji, Toshiyuki; Kurita, Jyoji
Chemistry Letters, 2006 , vol. 35, # 12 p. 1402 - 1403
参考文献
Matsuda, Naoki; Hirano, Koji; Satoh, Tetsuya; Miura, Masahiro
Angewandte Chemie - International Edition, 2012 , vol. 51, # 15 p. 3642 - 3645
